报告题目：Towards bacterial chemical glycobiology
报 告 人：李学臣 教授 香港大学
联 系 人：林双君 firstname.lastname@example.org
To study proteins carrying post-translational modifications, chemical biology approach provides new tools to gain new insights to their biological significance. Over the year, we have developed novel methods to generate homogeneous proteins with site-specific modification structures and modify proteins. In particular, bacterial protein glycosylation has emerged as a new entry to study bacterial pathogenesis and develop novel therapeutic intervention. For instance, P. aeruginosa 1244 pilin is glycosylated with a trisaccharide and the exact biological function of Pse-containing glycans in bacterial glycoproteins remains elusive. In this presentation, we will report our efforts in developing chemical biology tools to study bacterial glycobiology.