报告题目： Mechanisms that mediate the temporal organization of memories in the hippocampus
主讲人：Alcino J Silva
Alcino J Silva, Departments of Neurobiology, Psychiatry, and Psychology, Integrative Center for Learning and Memory, Brain Research Institute, University of California, Los Angeles, California 90095, USA
Studies of the molecular, cellular and circuit mechanisms of learning and memory have focused almost exclusively on how single memories are acquired, stored and edited. By comparison, very little is known about the mechanisms that mediate the temporal organization of memories in the hippocampus. Recently, our laboratory used state of the art in vivo imaging methods, chemogenetic and optogenetic approaches in the hippocampus and retrosplinial cortex, to uncover mechanisms that open and close the window for the organization of memory across time. Interestingly, we showed that aging disrupts these mechanisms and that this results in age dependent decline in how memories are linking across time. Importantly, studies in our laboratory have also identified strategies to rescue these deficits.