报告题目: ? Visualizing and Harnessing Polyketide Assembly Lines
报 ?告 人： Dr.Adrian Keatinge-Clay, Professor, Departments of Molecular Biosciences and Chemistry, the University of Texas at Austin
Modular polyketide synthases are the largest enzymes known to man and synthesize some of the most important human medicines. My lab seeks to understand the architectures of these molecular assembly lines and employ them in the synthesis of novel molecules and medicines. Over the last eight years, we have determined most of the crystal structures from modular polyketide synthases and have used them to construct models of the overall assembly line. We have also employed enzymatic domains and modules from these synthases in the chemoenzymatic syntheses of chiral building blocks.