报告题目：Synthetic Biology and Metabolic engineering of yeasts chemicals production
报 ?告 人：Hal S. Alper
Department of Chemical Engineering，The University of Texas at Austin
The field of Metabolic Engineering has recently undergone a transformation that has led to a rapid expansion of the chemical palate of cells. ?The incorporation of tools from synthetic biology and directed evolution has enabled a newfound control of cells. ?Now, it is conceivable to produce nearly any organic molecule of interest using a cellular host—from biofuels to biopolymers to pharmaceuticals. ?However, these feats require the ability to “hijack” native cellular machinery and metabolism and navigate the complexity inherent in cellular regulation. ?Of the many possible host organisms, yeasts are a growing host for industrial products and have many outstanding, biotechnologically-desirable native traits. ?This talk will describe recent advances in our laboratory for engineering both conventional (e.g. Saccharomyces cerevisiae) and non-conventional (e.g. Yarrowia lipolytica) yeasts for the production of important products such as organic acids and oleochemicals. ?This talk will emphasize the development of new tools for synthetic biology (especially synthetic promoters and terminators) and directed evolution along the way to pathway engineering. ?Collectively, these case studies demonstrate the power and utility of using yeasts as a production host for chemicals.
Dr. Hal Alper is an Associate Professor and Fellow of the Paul D. & Betty Robertson Meek Centennial Professorship in Chemical Engineering at The University of Texas at Austin. ?He earned his Ph.D. in Chemical Engineering from the Massachusetts Institute of Technology in 2006 and was a postdoctoral research associate at the Whitehead Institute for Biomedical Research from 2006-2008, and at Shire Human Genetic Therapies from 2007-2008. ?Dr. Alper also serves on the Graduate Studies Committee for the Cell and Molecular Biology Department and the Biochemistry Department. ?He is currently the Principal Investigator of the Laboratory for Cellular and Metabolic Engineering at The University of Texas at Austin where his lab focuses on metabolic and cellular engineering in the context of biofuel, biochemical, and biopharmaceutical production in an array of model host organisms. ?His research focuses on applying and extending the approaches of related fields such as synthetic biology, systems biology, and protein engineering. ?Dr. Alper has published over 70 articles and 8 book chapters that have been cited over 4900 times and has an h-index of 31. ?Dr. Alper is the recipient of the Camille and Henry Dreyfus New Faculty Award in 2008, the Texas Exes Teaching Award in 2009, the DuPont Young Investigator Award in 2010, the Office of Naval Research Young Investigator Award in 2011, the UT Regents’ Outstanding Teaching Award in 2012, the 2013 Biotechnology and Bioengineering Daniel I.C. Wang Award, the Jay Bailey Young Investigator Award in Metabolic Engineering in 2014, the 2014 Camille Dreyfus Teacher-Scholar Award, 2015 Society for Industrial Microbiology and Biotechnology Young Investigator Award, and 2016 ACS BIOT Young Investigator Award.