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Jinwei Zhu

Tenure-track Associate Professor

  • Tel:
  • Email: jinwei.zhu@sjtu.edu.cn
  • Address:
  • Lab Web: http://www.bio-x.cn/
  • Dr. Zhu received his PhD in Chemical Biology from Fudan University. He is currently the PI of Bio-X Institutes at Shanghai Jiao Tong University, focusing on biochemical and structural basis of polarized signaling transduction in neurons and kidney as well as etiology of related diseases such as psychiatric disorders and kidney diseases.

Selected Publications

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    Lin L#, Shi Y#, Wang M, Wang C, Lu Q, Zhu J*,1, Zhang R*. (2021) Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell Rep 34(8):108770. (1Lead Contact).

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    Zhang M#, Lin L#, Wang C*, Zhu J*. (2021) Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc Natl Acad Sci USA. 118(8) e2024465118.

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    Wang M#, Lin L#, Shi Y, He L, Wang C*, Zhu J*. (2020) Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. Biochem J 477(23):4623-4634.

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    Zhu J#,*, Zhou Q#, Xia Y, Lin L, Li J, Peng M, Zhang R*, Zhang M*. (2020) GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling. Mol Cell 79(5):782-796.e6.

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    Weng Z, Situ C, Lin L, Wu Z, Zhu J*, and Zhang R* (2019) Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun 10(1):51.
     

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    Lin L, Shi Y, Wang M, Wang C, Zhu J*,1, and Zhang R*. (2019) Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase. Structure 27(5):729-740. (1Lead contact).

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    Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R* and Zhu J* (2018) Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling. J Am Soc Nephrol 29(9):2362-2371.
     

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    Weng Z, Shang Y, Yao D, Zhu J*, and Zhang R* (2018) Structural basis of KANK1/KIF21A complex in crosstalk between dynamic microtubule and cell cortex. J Biol Chem 293(1):215-225.
     

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    Xia Y#, Shang Y#, Zhang R, and Zhu J* (2017) Structure of PSD95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain. Biochem J 474(16):2817-2828.
     

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    Zhu J, Shang Y, and Zhang M* (2016) Mechanistic Basis of MAGUKs-organized Complexes in Synaptic Development and Signalling. Nat Rev Neurosci 17(4):209-23.