Ya Guo

Tenure-track Associate Professor

  • Tel: +86-021-34204127
  • Email:
  • Address: Rm. 4A-411, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
  • PI, Sheng Yushou Center of Cell Biology and Immunology & Department of Genetics and Developmental Science, Shanghai Jiao Tong University. We are interested in understanding how genome is folded in three-dimensional space, and the correlation between genome organization and gene expression in mammalian cells.

Selected Publications

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    Guo Y, Xu Q, Canzio D, et al. CRISPR Inversion of CTCF Sites Alters Genome Topology and Enhancer/Promoter Function. Cell. 2015;162(4):900-910.


    Guo Y, Monahan K, Wu H, et al. CTCF/cohesin-mediated DNA looping is required for protocadherin α promoter choice. Proc Natl Acad Sci U S A. 2012;109(51):21081-21086.


    Jia Z, Li J, Ge X, Wu Y, Guo Y, Wu Q. Tandem CTCF sites function as insulators to balance spatial chromatin contacts and topological enhancer-promoter selection. Genome Biol. 2020;21(1):75.


    Cuartero S, Weiss FD, Dharmalingam G, et al. Control of inducible gene expression links cohesin to hematopoietic progenitor self-renewal and differentiation. Nat Immunol. 2018;19(9):932-941.


    Li J, Shou J, Guo Y, et al. Efficient inversions and duplications of mammalian regulatory DNA elements and gene clusters by CRISPR/Cas9. J Mol Cell Biol. 2015;7(4):284-298.