mg真人,mg真人在线

肖晗

副研究员

  • 电话:+86-021
  • 邮箱:smallhan@sjtu.edu.cn
  • 地址:上海市东川路800号生物药学楼#3-317
  • mg真人副研究员,博士生导师,从事微生物细胞工厂的构建,实现蘑菇真菌源重要代谢物的高效生物合成。基于合成生物学、基因组编辑等策略,挖掘决定细胞工厂优良性状的关键遗传因子并解析其机制。

学术经历

  • 2012年,获得中国科学院上海生命科学研究院微生物学博士学位;
  • 2012-2015年,在美国伊利诺伊大学厄巴那香槟分校从事博士后研究;
  • 2015-今,mg真人,副研究员;
  • 2019-今,mg真人,博士生导师;
  • 现任上海市生物工程学会合成生物学专业委员会委员、中国医药生物技术协会合成生物技术分会委员。

研究方向

Efficient Biomanufacturing

Develop and apply genome engineering tools to discover the genetic determinants for chassis cell construction regarding efficient biomanufacturing.

Mushroom Synthetic Biology

Develop genome engineering tools and smart response systems in mushroom for applicatons in efficient biosynthesis of secondary metabolites.

Mushroom Synthetic Biology

Develop genome engineering tools and smart response systems in mushroom for applicatons in efficient biosynthesis of secondary metabolites.

代表论著

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    Han Xiao*, Yue Zhang and Meng Wang* (2019). Discovery and engineering of cytochrome P450s for terpenoid biosynthesis. Trends Biotechnol, 37(6): 618-631.

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    Xiaoting Lan, Wei Yuan, Meng Wang* and Han Xiao* (2019). Efficient biosynthesis of antitumor ganoderic acid HLDOA using a dual tunable system for optimizing the expression of CYP5150L8 and a Ganoderma P450 reductase. Biotechnol Bioeng, 116(12): 3301-3311.

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    Zehua Bao, Mohammad HamediRad, Pu Xue, Han Xiao, Ipek Tasan, Ran Chao, Jing Liang and Huimin Zhao* (2018). Genome-scale engineering of Saccharomyces cerevisiae with single nucleotide precision. Nature Biotechnol, 36(6): 505-508.

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    Wen-Fang Wang, Han Xiao* (co-first author) and Jian-Jiang Zhong* (2018). Biosynthesis of a ganoderic acid in Saccharomyces cerevisiae by expressing a cytochrome P450 gene from Ganoderma lucidum. Biotechnol Bioeng, 115(7): 1842-1854.

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    Zehua Bao, Han Xiao (co-first author), Jing Liang, Lu Zhang, Xiong Xiong, Ning Sun, Tong Si and Huimin Zhao* (2015). Homology-Integrated CRISPR-Cas (HI-CRISPR) system for one-step multigene disruption in Saccharomyces cerevisiae. ACS Synth Biol 4(5):585-594. (入选SCI高被引论文)

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    Pingan Wang, Han Xiao* and Jian-Jiang Zhong* (2020). CRISPR-Cas9 assisted functional gene editing in the mushroom Ganoderma lucidum. Appl Microbiol Biotechnol, 104: 1661-1671.

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    Han Xiao and Huimin Zhao* (2014). Genome-wide RNAi screen reveals the E3 SUMO-protein ligase gene SIZ1 as a novel determinant of furfural tolerance in Saccharomyces cerevisiae. Biotechnol Biofuels 7:78.

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    Han Xiao* and Jian-Jiang Zhong* (2016). Production of useful terpenoids by higher-fungus cell factory and synthetic biology approaches. Trends Biotechnol 34(3): 242-255.

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    Xiaoting Lan and Han Xiao* (co-first author) (2020). Cyclodextrins facilitate the efficient secretion of an anti-tumor triterpenoid ganoderic acid HLDOA by Saccharomyces cerevisiae. J Biosci Bioeng, 130(2): 142-148.

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    Han Xiao, Zhilin Li, Yu Jiang, Yunliu Yang, Weihong Jiang, Yang Gu* and Sheng Yang* (2012). Metabolic engineering of d-xylose pathway in Clostridium beijerinckii to optimize solvent production from xylose mother liquid. Metab Eng 14(5): 569-578.

获奖情况

  • 2017年,荣获mg真人晨星优秀青年学者副教授支持计划(B类)
  • 2019年,荣获日本生物技术学会授予的DaSilva Award
  • 2019、2020年,荣获mg真人优秀班主任
  • 国家自然科学基金面上项目, 31971344,基因组改造酿酒酵母高效合成抗肿瘤灵芝酸HLDOA, 2020/01-2023/12, 主持,在研
  • 科技部重点研发项目子课题,2018YFA0900600,萜类化合物代谢模块的优化适配策略研究,2019/07-2024/06,主持,在研
  • 上海市自然科学基金探索类项目,18ZR1420300, 酿酒酵母高通量筛选合成灵芝酸关键CYP450酶研究平台的构建,2018/06-2021/05,主持,在研
  • mg真人医工交叉项目,YG2017MS82,灵芝酸T精准治疗肺腺癌及克服靶向药物耐药性的临床前研究,2018/01-2020/12,合作主持,结题
  • 上海市自然科学基金探索类项目,17ZR144890,高等真菌基因敲除新技术的研究,2017/05-2020/04,主持,结题
  • 国家自然科学基金青年项目,31600071,酿酒酵母合成灵芝酸类似物的研究,2017/01-2019/12,主持,结题
  • 教育部留学回国人员基金,15002487,高等真菌生产抗癌次级代谢物灵芝酸的代谢工程研究,2015/06-2017/06,主持,结题

承担项目

学生培养

  • 在读学生
  • 毕业学生