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朱金伟

长聘教轨副教授

  • 电话:
  • 邮箱:jinwei.zhu@sjtu.edu.cn
  • 地址:mg真人徐汇校区Bio-X研究院
  • 实验室网址:http://www.bio-x.cn/
  • 朱金伟,mg真人长聘教轨副教授,博士生导师。综合利用生物化学、结构生物学及分子细胞生物学等手段,研究细胞极性相关蛋白复合物在神经信号转导中的生化及结构基础,同时关注与细胞极性失调相关的重大疾病的发病机制研究。

研究方向

神经信号转导及可塑性的生化和结构基础

突触发育过程的生化和结构机理;突触可塑性过程的分子机制;神经精神疾病的结构生物学基础

肾小球滤过屏障的结构基础

裂孔隔膜(slit diaphragm)组装的生化和结构基础;肾病综合征发病的分子机制;细胞连接,细胞极性和细胞迁移的结构生物学

代表论著

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    Lin L#, Shi Y#, Wang M, Wang C, Lu Q, Zhu J*,1, Zhang R*. (2021) Phase separation-mediated condensation of Whirlin-Myo15-Eps8 stereocilia tip complex. Cell Rep 34(8):108770. (1Lead Contact).

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    Zhang M#, Lin L#, Wang C*, Zhu J*. (2021) Double inhibition and activation mechanisms of Ephexin family RhoGEFs. Proc Natl Acad Sci USA. 118(8) e2024465118.

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    Wang M#, Lin L#, Shi Y, He L, Wang C*, Zhu J*. (2020) Structure of the FERM domain of a neural scaffold protein FRMPD4 implicated in X-linked intellectual disability. Biochem J 477(23):4623-4634.

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    Zhu J#,*, Zhou Q#, Xia Y, Lin L, Li J, Peng M, Zhang R*, Zhang M*. (2020) GIT/PIX Condensates Are Modular and Ideal for Distinct Compartmentalized Cell Signaling. Mol Cell 79(5):782-796.e6.

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    Weng Z, Situ C, Lin L, Wu Z, Zhu J*, and Zhang R* (2019) Structure of BAI1/ELMO2 complex reveals an action mechanism of adhesion GPCRs via ELMO family scaffolds. Nat Commun 10(1):51.
     

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    Lin L, Shi Y, Wang M, Wang C, Zhu J*,1, and Zhang R*. (2019) Rab35/ACAP2 and Rab35/RUSC2 Complex Structures Reveal Molecular Basis for Effector Recognition by Rab35 GTPase. Structure 27(5):729-740. (1Lead contact).

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    Weng Z, Shang Y, Ji Z, Ye F, Lin L, Zhang R* and Zhu J* (2018) Structural basis of highly specific interaction between Nephrin and MAGI1 in slit diaphragm assembly and signaling. J Am Soc Nephrol 29(9):2362-2371.
     

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    Weng Z, Shang Y, Yao D, Zhu J*, and Zhang R* (2018) Structural basis of KANK1/KIF21A complex in crosstalk between dynamic microtubule and cell cortex. J Biol Chem 293(1):215-225.
     

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    Xia Y#, Shang Y#, Zhang R, and Zhu J* (2017) Structure of PSD95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain. Biochem J 474(16):2817-2828.
     

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    Zhu J, Shang Y, and Zhang M* (2016) Mechanistic Basis of MAGUKs-organized Complexes in Synaptic Development and Signalling. Nat Rev Neurosci 17(4):209-23.

获奖情况

  • 2020年获得长三角神经科学青年科学家奖