mg真人,mg真人在线

丁伟

长聘教轨副教授

  • 电话:+86-021
  • 邮箱:weiding@sjtu.edu.cn

学术经历

  • 教育经历:
  • 2006-2010:兰州大学生命科学院和中科院上海有机化学研究所联合培养,博士
  • 2001-2005:兰州大学生命科学院,本科
  • 工作经历:
  • 2019-至今:mg真人,特别研究员、博导
  • 2013-2018:兰州大学生命科学院,副教授、硕导
  • 2010-2012:德国Saarland University,药物生物技术系,博士后

研究方向

重要生物活性天然产物的生物合成机制和合成生物学研究

重要生物活性天然产物的生物合成机制和合成生物学研究

极端环境微生物中活性小分子和高效酶的发现

极端环境微生物中活性小分子和高效酶的发现

酶催化机制的多样性和定向进化研究

酶催化机制的多样性和定向进化研究

重要临床药物中间体的生物催化和微生物工业菌种的代谢工...

重要临床药物中间体的生物催化和微生物工业菌种的代谢工程改造

代表论著

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    Tianlv Mo, Dhanaraju Mandalapu, Hong Yuan, Wei Ding* and Qi Zhang*.Convergent evolution of the Cys decarboxylases involved in aminovinyl-cysteine (AviCys) biosynthesis. FEBS Letters. 2019, 593(6):573-580.

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    Wei Ding#, Ning Yuan#, Dhanaraju Mandalapu, Tianlu Mo, Suwei Dong* and Qi Zhang*. Cypemycin Decarboxylase CypD Is Not Responsible for Aminovinyl–Cysteine (AviCys) Ring Formation. Org. Lett., 2018, 20 (23):7670–7673.

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    Wei Ding, Tianlu Mo, Dhanaraju Mandalapu, Qi Zhang*. Substrate specificity of the cypemycin decarboxylase CypD. Synth Syst Biotechnol. 2018, 3(3):159-162

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    Yujie Wu, Runze Wu, Dhanaraju Mandalapu, Xinjian Ji, Tuo Chen, Wei Ding and  Qi Zhang. Radical SAM-dependent adenosylation catalyzed by L-tyrosine lyases. Org Biomol Chem. 2018, 17(7):1809-1812.

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    Xinjian Ji, Dhanaraju Mandalapu, Jinduo Cheng, Wei Ding, Qi Zhang*.Expanding the Chemistry of the Class C Radical SAM Methyltransferase NosN by Using an Allyl Analogue of SAM. Angew Chem Int Ed Engl. 2018, 57(22):6601-6604.

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    Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, and Qi Zhang. Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity.J Org Chem. 2018, 83(13):7271-7275.

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    Thongkongkaew Tawatchai, Ding Wei, Bratovanov Evgeni, Oueis Emilia, Garcia Altares Maria, Zaburannyi Nestor, Harmrolfs Kirsten, Zhang Youming, Scherlach Kirstin, Mueller Rolf* and Hertweck Christian*. Two Types of Threonine-Tagged Lipopeptides Synergize in Host Colonization by Pathogenic Burkholderia Species. ACS Chemical Biology. 2018, 13(5): 1370-1379.

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    Wei Ding, Wenjuan Ji, Yujie Wu,  Runze Wu, Wan-Qiu Liu, Tianlu Mo, Junfeng Zhao, Xiaoyan Ma, Ping Xu, Boping Tang*, Yi Yu* and Qi Zhang*. Biosynthesis of the Nosiheptide Indole Side Ring Centers on a Cryptic Carrier Protein NosJ. Nature Communications. 2017, 8(1):437.

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    Wei Ding, Yongzhen Li, Junfeng Zhao, Xinjian Ji, Tianlu Mo, Haocheng Qianzhu, Zixin Deng, Yi Yu, and Qi Zhang*. Catalytic Mechanism of the Class C radical S-Adenosylmethionine Methyltransferase. Angew. Chem. Int. Ed. 2017, 56, 3857 -3861.

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    Wei Ding, Yujie Wu, Xinjian Ji, Haocheng Qianzhu, Fener Chen, Zixin Deng, Yi Yu and Qi Zhang*. Nucleoside-linked Shunt Products in the Reaction Catalyzed by the Class C Radical S-Adenosylmethionine Methyltransferase NosN. Chemical Communications. 2017, 53, 5235-5238.