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郭熙志

特聘教授

  • 电话:+86-021-34206736
  • 邮箱:xzguo2005@sjtu.edu.cn
  • 地址:东川路800号生物药学楼#1-205

学术经历

  • 武汉大学学士,中科院上海植物生理生态所博士,美国NIH人类基因组研究所博士后。

研究方向

骨发育与代谢

    以基因敲除小鼠为模型,研究成骨细胞和破骨细胞分化,骨质重塑的调控过程,分析骨质疏松,骨关节炎等退行性疾病的病理机制,为治疗这些疾病探寻药物靶点。

间充质干细胞的衰老调控

  间充质干细胞的衰老是肌体许多衰老疾病的细胞学基础。清理衰老细胞(senolysis)可以作为治疗衰老相关疾病的重要策略。我们研究发现Foxp1基因调控骨髓间充质干细胞的衰老,这有可能作为调控衰老疾病的重要靶点之一。

脂肪代谢与糖尿病

   肥胖和伴随的糖尿病成为繁荣时代的重要灾难之一。我们尝试从人类进化的角度,研究人类基因组变化,生活方式的改变等对肥胖和糖尿病形成的调控作用。

代表论著

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    Foxp2 regulates anatomical features that may be relevant for vocal behavior and bipedal locomotion. 

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    Foxp1 controls cell fate commitment and senescence of mesenchymal stem cells during skeletal aging

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    Bone marrow fibrosis with fibrocytic and immunoregulatory responses induced by β-catenin activation in osteoprogenitors

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    Ablation of Wntless in endosteal niches impairs lymphopoiesis rather than HSC maintenance.

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    Foxp1/2/4 regulate endochondral ossification as a suppresser complex.

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    Ectodermal Wnt signaling regulates abdominal myogenesis during ventral body wall development. 

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    Osteoblastic Wnts differentially regulate bone remodeling and the maintenance of bone marrow mesenchymal stem cells.

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    Wnts-mediated reciprocal regulation between cartilage and bone development during endochondral ossification.

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    Ndrg2 regulates vertebral specification in differentiating somites. 

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    Wls-mediated Wnts differentially regulate distal limb patterning and tissue morphogenesis.