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杨选明

长聘教轨副教授

  • 电话:+86-021-34205287
  • 邮箱: xuanmingyang@sjtu.edu.cn

学术经历

  • 1998.9-2002.7:北京大学生命科学学院 理学学士
  • 2002.9-2009.5:中国科学院生物物理研究所感染与免疫研究中心 博士
  • 2009.6-2014.6:美国芝加哥大学病理学系 博士后
  • 2014.6-2014.10: 美国芝加哥大学 助理研究员
  • 2014.11至今:mg真人 特别研究员

研究方向

研究肿瘤微环境中的各种细胞组分对肿瘤免疫的抑制机理,...

研究肿瘤微环境中的各种细胞组分对肿瘤免疫的抑制机理,发现新的肿瘤治疗靶点

发展基于抗体的靶向肿瘤免疫治疗手段

发展基于抗体的靶向肿瘤免疫治疗手段

发展基于T细胞修饰的细胞过继性肿瘤治疗手段

发展基于T细胞修饰的细胞过继性肿瘤治疗手段

发展基于重组蛋白以及免疫活化的肿瘤疫苗和病原微生物疫...

发展基于重组蛋白以及免疫活化的肿瘤疫苗和病原微生物疫苗

代表论著

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    Xuanming Yang, Xunmin Zhang, Yonglian Sun, Tony Tu, Mendy Miller, Yang-Xin Fu. A BTLA-Mediated Bait and Switch Strategy Permits Listeria Expansion in CD8α(+) DCs to Promote Long-Term T Cell Responses. Cell Host & Microbe. 2014 Jul 9;16(1):68-80 

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    Xiaohuan Guo, Ju Qiu, Tony Tu, Xuanming Yang, Liufu Deng, Robert A. Anders, Liang Zhou, Yang-Xin Fu. Induction of Innate Lymphoid Cell-Derived Interleukin-22 by the Transcription Factor STAT3 Mediates Protection against Intestinal Infection. Immunity. 2014 Jan 7. pii: S1074-7613(13)00555-4. 

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    Xuanming Yang, Xunmin Zhang, May Lynne Fu, Ralph R. Weichselbaum, Thomas F. Gajewski, Yajun Guo, Yang-Xin Fu. Targeting the tumor microenvironment with interferon-? bridges innate and adaptive immune responses. Cancer Cell. 2014 Jan 13;25(1):37-48. 

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    Ying He, Jikun Zha, Yamin Wang, Wenhua Liu, Xuanming Yang, and Ping Yu. Tissue damage-associated "danger signals" influence T-cell responses that promote the progression of preneoplasia to cancer. Cancer Res. 2013 Jan 15;73(2):629-39. 

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    Xuanming Yang, Xunmin Zhang, Eric Mortenson, Olga Radkevich-Brown, Yang Wang, Yang-Xin Fu. Cetuximab-mediated Tumor Regression Depends on Innate and Adaptive Immune Responses. Molecular Therapy. 2013 Jan;21(1):91-100 

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    Xuanming Yang, Eric D Mortenson , Yang-Xin Fu. Targeting and utilizing primary tumors as live vaccines: changing strategies. Cell Mol Immunol. 2011 Nov 21. doi: 10.1038/cmi.2011.49. 

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    Qi Da*, Xuanming Yang*, Xiaoqi Li, Youli Xu, Guangxia Gao, Genhong Cheng and Hong Tang. TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I J Immunol 2011;186;3023-3030 (*, Co-first Author) 

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    SaeGwang Park, Zhujun Jiang, Eric D. Mortenson, Liufu Deng, Olga Radkevich-Brown, Xuanming Yang, Husain Sattar, Yang Wang, Nicholas K. Brown, Mark Greene, Yang Liu, Jie Tang, Shengdian Wang, Yang-Xin Fu. The therapeutic effect of anti-HER2/neu antibody depends on both innate and adaptive immunity. Cancer Cell. 2010 Aug 9;18(2):160-70. 

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    Xiaoqi Li, Xuanming Yang, Youli Xu, Xuejun Jiang, Fajun Nan, Hong Tang. Troglitazone inhibits cell proliferation by attenuation of Epidermal Growth Factor Receptor Signaling independent of Peroxisome Proliferator-activated Receptor gamma. Cell Research. 2009: 720-732). 

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    Jie Zhao, Xuanming Yang, Sogyong Auh, Kwang Dong Kim, Hong Tang and Yang-Xin Fu. Do adaptive immune cells suppress or activate innate immunity? Trends Immunol. 2009 Jan;30(1):8-12. 

获奖情况

  • 2011年获北京市科学技术奖一等奖