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Dan Li

Special Researcher/Tenure-track Associate Professor

  • Tel: +86-021
  • Email: lidan2017@sjtu.edu.cn
  • Address: Bio-X Building, Room 305, Xuhui campus
  • Dr. Li joined the Bio-X Institutes at Shanghai Jiao Tong University as a principle investigator in 2017. She received her Ph.D. at the Peking University, followed by working at the University of California, Los Angeles, with Dr. David Eisenberg as a postdoctoral fellow.

Education and Research Experience

  • Dr. Li joined the Bio-X Institutes at Shanghai Jiao Tong University as a principle investigator in 2017.
  • She received her Ph.D. at the Peking University, followed by working at the University of California, Los Angeles, with Dr. David Eisenberg as a postdoctoral fellow.

Research Interests

Molecular mechanism of protein phase separation and amyloid aggregation

Molecular mechanism of protein phase separation and amyloid aggregation

Protein homeostasis in aging and neurodegenerative diseases

Protein homeostasis in aging and neurodegenerative diseases

Selected Publications

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    Dan Li and Cong Liu, Hierarchical chemical determination of amyloid polymorphs in neurodegenerative disease, Nature Chemical Biology, 2021, Jan 11.

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    Yunpeng Sun#, Kun Zhao#, Wencheng Xia, Jinge Gu, Yeyang Ma, Xinrui Gui, Xia Zhang, Yanshan Fang, Bo Sun, Cong Liu*, Dan Li* The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure, Nature Communications, 2020, Dec 11.

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    Jinge Gu , Zhenying Liu , Shengnan Zhang , Yichen Li , Wencheng Xia , Chen Wang , Huaijiang Xiang , Zhijun Liu , Li Tan , Yanshan Fang , Cong Liu* , Dan Li*,  Hsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles, PNAS, 2020, Dec 8.

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    Zhao, K., Li, Y., Liu, Z., Long, H., Zhao, C., Luo, F., Sun, Y., Tao, Y., Su, X.-D., Li, D.#, Li, X.#, Liu, C.#, Parkinson’s disease associated mutation E46K of α-synuclein triggers the formation of a distinct fibril structure. Nature Communications, 2020 , 2020 May 26.

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    Lu J, Zhang S, Ma X, Jia C, Liu Z, Huang C, Liu C#, Li D.#, Structural basis of the interplay between α-synuclein and Tau in regulating pathological amyloid aggregation. J. Biol. Chem. 2020 Apr 13.

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    Sun, Y., Hou, S., Zhao, K., Long, H., Liu, Z., Gao, J., Zhang, Y., Su, X. D., Li, D.#, Liu, C.#. Cryo-EM structure of full-length α-synuclein amyloid fibril with Parkinson’s disease familial A53T mutation, Cell Research, 2020 Apr;30(4):360-362.

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    Gui, X., Luo, F., Li, YC, Zhou, H., Qin,Z., Liu, ZY, Gu, JG, Xie, MY, Zhao, K., Dai, B., Shin, WS, He, JH, He, L., Jiang, L., Zhao, ML, Sun, B., Li, XM, Liu, C.#, Li, D.# Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly, Nature Communications, 2019 May 1;10(1):2006.

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    Lu, J.#, Cao, Q.#, Wang, C.#, Zheng, J., Luo, F., Xie, J., Li, Y., Ma, X., He, L., Eisenberg, D., Nowick, J., Jiang, L.#, Li, D.#, Structure-Based Peptide Inhibitor Design of Amyloid-b Aggregation, Frontiers in Molecular Neuroscience, 2019 Mar 4;12:54.

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    Li, Y.*, Zhao, C.*, Luo, F.*, Liu, Z., Gui, X., Luo, Z., Zhang, X., Li, D.#, Liu, C.#, Li, X.# Amyloid fibril structure of alpha-synuclein determined by cryo-electron microscopy. Cell Research 2018 Sep;28(9):897-903.

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    Li, D.#, Liu, C.#. Better together: a hybrid amyloid signals necroptosis. Cell 2018 Volume 173, Issue 5, p1068–1070, 17 May.