Yi Xiao

Special Researcher/Tenure-track Associate Professor

  • Tel: +86-021-34208601
  • Email:
  • Address: Xitong Building (Room C404), 800 Dongchuan RD. Minhang District, Shanghai, China

Education and Research Experience

  • A member of the Editorial Board of Applied and Environmental Microbiology 2019-

Research Interests


Development of CRISPR-associated tools for genome editing and regulation.

Development of genetically-encoded biosensors for screening and dynamic control.


Biosynthesizing high-value added bioproducts via cell factories.

Selected Publications

  • ?  

    Ruilian Yao#, Di Liu#, Xiao Jia, Yuan Zheng, Wei Liu, Yi Xiao*. (2018) CRISPR-Cas9/Cas12a biotechnology and application in bacteria. Synthetic and Systems Biotechnology. 3(3):135-149


    Yi Xiao, Shaojie Wang, Sarah Rommelfanger, Andrea Balassy, Carlos Barba-Ostria, Pengfei Gu, Jonathan M. Galazka, Fuzhong Zhang*. (2018) Developing a Cas9-based tool to engineer native plasmids in Synechocystis sp. PCC 6803. Biotechnology and Bioengineering 115(9):2305-2314.


    Yi Xiao, Wen Jiang, Fuzhong Zhang. (2017) Developing a genetically encoded, cross-species biosensor for detecting ammonium and regulating biosynthesis of cyanophycin. ACS Synthetic Biology. 6 (10), pp 1807–1815


    Yi Xiao, Christopher H. Bowen, Di Liu, Fuzhong Zhang. (2016) Exploiting nongenetic cell-to-cell variation for enhanced biosynthesis. Nature Chemical Biology 12, 339–344


    Xiao Jia#, Shun Zhang#, Jiawei Li, Juan Xia, Ruilian Yao, Xinqing Zhao, Bing Wu , Fengwu Bai, Yi Xiao*. (2020) Engineered bacterial biofloc formation enhancing phenol removal and cell tolerance. Applied Microbiology and Biotechnology 104(3), 1187-1199

  • ?  

    Xiaofeng Wu, Pujie Wang,  Jiawei Li,  Shun Zhang, Xiao Jia, Ruilian Yao, Yi Xiao*. (2020) Construction of nisin whole-cell biosensors. (In press)

Teaching Experiences

  • 2019 Fundamentals of natural science
  • National 1000 Youth Talents Program 2018-
  • National Key R&D Program of China 2019-
  • National Natural Science Foundation of China 2019-
  • Science and Technology Commission of Shanghai Municipality 2018-

Selected Grants