mg真人,mg真人在线

夏小霞

教授/长聘副教授

  • 电话:+86-021-34207254
  • 邮箱:xiaoxiaxia@sjtu.edu.cn
  • 地址:东川路800号生物药学楼3-303
  • mg真人教授,博士生导师,聚焦蛋白材料合成生物学研究。通过肽段模块的挖掘及重构,仿生及再设计人工蛋白质,在宿主微生物体内构建亚细胞器,对细胞生命活动进行代谢重塑;在体外制备智能仿生及生物医用材料。近5年在Nat Chem Biol等高水平期刊发表论文27篇,他引1100余次。

学术经历

  • 2009年1月获韩国科学技术院(KAIST) 化学与生物分子工程博士学位,之后在韩国KAIST及美国Tufts大学从事博士后研究,于2012年9月加入mg真人,入选上海市浦江人才计划(A类)。
  • 担任国际期刊Biotechnology Journal,ACS Biomaterials Science&Engineering及Metabolic engineering communications编委。

研究方向

人工无膜细胞器

解析蛋白相变组装机制,建立无膜细胞器的动态响应调控策略,发展微生物代谢时空调控的平台技术

人工蛋白材料的高通量筛选

建立人工蛋白材料分子动力学模拟、高通量合成及筛选新方法

人工蛋白材料创制

基于人工蛋白质的相变/组装构筑先进功能材料

代表论著

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    Qin N, Qian ZG, Zhou C, Xia XX*, Tao TH*. 3D electron-beam writing at sub-15 nm resolution using spider silk as a resist. Nat Commun 2021, 12: 5133.

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    Wei SP†, Qian ZG†, Hu CF†, Pan F, Chen MT, Lee SY, Xia XX*. Formation and functionalization of membraneless compartments in Escherichia coli. Nat Chem Biol, 2020, 16(10):1143-1148. 

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    Qian ZG, Pan F, Xia XX*. Synthetic biology for protein-based materials. Curr Opin Biotechnol, 2020, 65:197-204.

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    Song WW†, Qian ZG†, Liu H, Chen HF, Kaplan DL, Xia XX*. On-demand regulation of dual thermosensitive protein hydrogels. ACS Macro Lett 2021, 10(4):395-400.

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    Hu CF†, Qian ZG†, Peng Q, Zhang Y, Xia XX*. Unconventional spidroin assemblies in aqueous dope for spinning into tough synthetic fibers. ACS Biomater Sci Eng 2021, 7: 3608–3617.

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    Huang SC†, Fan RX†, Tian KK, Xia XX*, Qian ZG*. Controllable fibrillization reinforces genetically engineered protein elastomer hydrogels. Biomacromolecules, 2021, 22: 961-970.

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    Jiang J†, Zhang S†, Qian Z, Qin N, Song W, Sun L, Zhou Z, Shi Z, Chen L, Li X, Mao Y, Kaplan DL, Gilbert Corder SN, Chen X, Liu M, Omenetto FG, Xia XX*, Tao TH*. Protein bricks: 2D and 3D bio-nanostructures with shape and function on demand. Adv Mater, 2018, 1705919. (Selected as inside back cover).

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    Qin N†, Zhang S†, Jiang J, Corder SG, Qian Z, Zhou Z, Lee W, Liu K, Wang X, Li X, Shi Z, Mao Y, Bechtel HA, Martin MC, Xia XX, Marelli B, Kaplan DL, Omenetto FG*, Liu M*, Tao TH*. Nanoscale probing of electron-regulated structural transitions in silk proteins by near-field IR imaging and nano-spectroscopy. Nat Commun, 2016, 7: 13079.

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    Zhou Z†, Zhang S†, Marelli B*, Xia XX*, Tao TH*. Engineering the future of silk materials through adaptable modification and advanced manufacturing. Adv Mater, 2018, 1706983.

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    Xia XX†, Qian ZG†, Ki CS, Park YH, Kaplan DL, Lee SY*. Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber. PNAS 2010, 107 (32): 14059-14063.

教学情况

  • 本科生专业课  代谢工程
  • 研究生核心课  合成生物学